Disulfiram-like Reaction With Metronidazole: An Unsuspected Culprit

Disulfiram reaction in an artist exposed to solvents.

This case report describes an artist on treatment for alcoholism with disulfiram (Antabuse) who suffered chronic symptoms similar to those of a disulfiram alcohol reaction, which we attribute to his occupational exposure to products containing alcohol and other solvents. Symptoms abated with strict precautions to prevent exposure, although gradually returned over the course of months, causing h...

The disulfiram--ethanol reaction: a review.

Lipoid pneumonia; an unsuspected diagnosis.

CASE REPORT. A 74-year-old female was admitted with a two month history of increasing breathlessness and malaise. Prior to this she had been fit and active. She had begun to feel unwell and developed a cough, initially producing pink sputum which later became green in colour. Two months prior to admission she developed severe right sided pleuritic chest pain on coughing. Initially she was breat...

Severe hypotension and ischemic stroke after disulfiram-ethanol reaction.

Disulfiram (tetraethylthiuram disulfide) has been used for almost 60 years in the treatment of alcohol addiction. It causes aversive behavior due to disulfiram-ethanol reaction (DER). The classical DER includes flush, sweating, tremor, nausea, vomiting, tachycardia, moderate decrease in blood pressure and restlessness. Complete recovery is the usual outcome in clinical settings. Life-threatenin...

Pulmonary embolism: an unsuspected killer.

The presentation of PE is often subtle and may mimic other diseases. Many pulmonary emboli invariably preclude diagnosis by their occult nature or by leading to rapid death from cardiopulmonary arrest. In patients who do manifest symptoms from PE, accurate diagnosis is essential. Often it is difficult to distinguish the vague symptoms of PE from other diagnoses, such as acute coronary syndrome,...